Phenotypic Analysis of Pneumococcal Polysaccharide-Specific B Cells
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Comment on "phenotypic analysis of pneumococcal polysaccharide-specific B cells".
The phenotype of B cells responsible for the production of anti-pneumococcal polysaccharide Ab has been unclear. Although individuals that respond poorly to the 23-valent pneumococcal polysaccharide (PPS) vaccine, Pneumovax, such as children <2 y, the asplenic, and a subset of common variable immunodeficiency patients, are profoundly deficient or lack IgM memory cells (CD27(+)IgM(+)), they are ...
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